CA-125卵巢癌的筛查可能会拯救生命

来自世界上最大的卵巢癌筛查研究的新结果表明，从称为CA-125的简单血液检测开始的策略可能导致卵巢癌死亡较少。这是因为基于CA-125的策略在早期阶段鉴定了更多女性患有卵巢癌的女性。

While the study is a significant step forward for early detection, it may be years before ovarian cancer screening guidelines change. More research needs to be done before the blood test is used as screening for all women, saysKaren Lu，M.D.,妇科肿瘤和生殖医学椅。

“这项研究表明,我们实际上可能减少aths from a highly lethal cancer, but it's a different question as to whether we're ready to recommend that all women get screened for ovarian cancer," Lu says. "I think that we're close, but we need a few more years of results before we say that every woman should have it."

卵巢癌CA-125如何筛选战略工作？
The screening strategy asks women to have a yearly CA-125 blood test. Then, the strategy relies on a scientific method called the Risk of Ovarian Cancer Algorithm (ROCA) to determine if women should go on to have an ultrasound and potentially surgery.

MD Anderson一直在研究CA-12188bet体育网址5，几十年。在20世纪80年代，罗伯特巴斯特，M.D.，MD Anderson的翻译研究副总裁发现，血液中的某些水平的Ca188bet体育网址-125蛋白可能表明卵巢癌复发。使用CA-125和Roca的卵巢癌筛查研究已经在MD Anderson进行。

最近的研究，英国的卵巢癌筛查的协同试验，是世界上最大的卵巢癌早期检测研究。它旨在确定筛选是否可挽救生命。超过20万名女性参加了这项研究。

The study showed that the CA-125-based screening strategy results in earlier stage ovarian cancers being detected. The study results showed that the strategy may reduce the number of ovarian cancer deaths by 20%. This means about 15 ovarian cancer deaths could be prevented for every 10,000 women who receive annual screening for seven to 11 years.

Three more years of follow-up research are necessary to confirm these findings. In addition to the benefits of screening, harms also need to be considered. For every three women who had surgery, one had ovarian cancer and two women did not.

Who needs ovarian cancer screening?
并非所有女性都需要筛选卵巢癌。目前，为患有BRCA1或BRCA2遗传突变的40岁以上的女性建议年度或两次筛查，这增加了乳腺癌和卵巢癌的人员的机会。该筛选包括Ca-125血液测试和经阴道超声波。40岁以后，卢博士建议卵巢癌风险高的妇女将其输卵管和卵巢除去，以防止它们发育卵巢癌。

如果您担心您可能面临卵巢癌的风险，请与您的医生讨论您的个人和家庭癌症历史。

Ovarian cancer is one of the diseases MD Anderson is focusing on as part of our Moon Shots Program to dramatically reduce cancer deaths. Learn more about our Breast and Ovarian Cancers Moon Shot.