Through our research, we are focused on identifying molecules that are critical for ER-negative breast cancer development and progression by:
鉴定参与乳腺癌细胞生长和转化的关键分子途径
Investigating the functions of signaling molecules activated by these pathways
Developing strategies targeting these signaling molecules that are capable of blocking or interfering with transformation and cell growth
Carrying these strategies forward to clinical trials focused on the prevention or treatment of breast cancer
我们使用了广泛的研究，以支持这项研究，包括基因表达的分子研究，正常和癌前人类乳腺癌细胞的细胞生188bet体育网址物学研究，in vivostudies using gene therapy and small molecule inhibitors in transgenic and knockout mice. Members of the Powel Brown Lab use whole genome approaches at the DNA, RNA, proteomic and metabolomic levels to investigate breast biology and transformation. Scientists also use systems biology, bioinformatics and high-throughput screening techniques to identify novel signal transduction pathways, which they then target in developing new breast cancer therapies. Through these studies we seek to identify new strategies to treat and prevent breast cancer.
We currently have projects supported by an NIH R01 grant, DOD grants, BCRF grants, and a Susan G. Komen for the Cure Promise grant to conduct studies to identify new targets for the treatment and prevention of breast cancer. The studies that support this research center on the active and complete training of pre- and post-doctoral students and senior research scientists in a broad range of techniques currently supporting cancer research, including: molecular biology, genetics, signal transduction, bioinformatics and systems biology.
