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安妮孟德尔索恩长期支持休斯顿的文化和慈善社区，特别是那些与教育，医疗保健，表演艺术相关的文化和慈善社区以及对科学的公众了解。她担任休斯顿自然科学博物馆的董事会和休斯顿区域教学委员会。Anne and her husband, John Mendelsohn, M.D., president of MD Anderson, have received a number of honors together, including the Woodrow Wilson Award for Public Service, the Houston Technology Center Celebration of Entrepreneurs Award and the Teach for America - Houston's annual award for advancing education.