September 21, 2017
How to handle side effects of CAR-T cell therapy
BY Scott Merville
免疫细胞为基础的治疗打开一个新的前沿用于癌症治疗携带独特的，潜在的致命副作用为肿瘤学家一个新的挑战，一个解决由得克萨斯大学MD安德森癌症中心大学临床医师为首拟议准则系统处理团队与这些药物的毒性。
Theirwork, published最近在自然评论：临床肿瘤学，面对嵌合抗原受体的T细胞，已知为CAR T细胞，白血细胞基因工程化以撞击细胞与它们的表面上的特定目标的两个主要的副作用。
“CAR T细胞为患者提供某些血癌和有希望用于更广泛的用途中改善的疾病应答的一个全新的水平，”说伊丽莎白Shpall, M.D., deputy chair and professor ofStem Cell Transplantation and Cellular Therapyat MD Anderson.
“The algorithms that we published are conservative, detailed, and will help us save lives as we move forward with these exciting but also more toxic therapies,” Shpall said.
基于超过100名患者在MD安德森，莫菲特癌症中心在坦帕，西尔维188bet体育网址斯特癌症中心在迈阿密大学和梅奥诊所癌症中心治疗的审查涵盖范围广泛的许多机构CAR-T疗法的研究，包括见解明尼苏达州罗切斯特市。
患者由合作作者与CAR T细胞正在开发在四个不同的公司对白血病和攻击白血细胞称为B细胞淋巴瘤的治疗。它们靶向CD19，恶性和正常B细胞的表面上发现的蛋白质。
细胞因子风暴，脑应激和安全
Two side effects have emerged during clinical trials that were previously uncommon to cancer treatments:
- Cytokine release syndrome (CRS), also known as cytokine storm, an escalated immune response that causes flu-like symptoms and can be fatal.
- Neurological toxicity that the researchers have named CAR-T-cell-related encephalopathy syndrome (CRES), which can sometimes lead to lethal swelling in the brain.
无论CRS和CRES是可以治疗的，早期识别，以迅速改善重要。该审查提供具体建议预处理制剂，期间和之后CARŤ输注监测患者，识别和分期新兴CRS和CRES，并且取决于它们的严重程度的那些副作用定制治疗。
了解更多关于在研究中MD安德森新闻room。