Can this protein prevent or kill breast cancer tumors?

每位家长都知道的一句格言“喂感冒，饿死发烧。”在癌症中，但是，究竟如何喂养或饿死肿瘤并不容易确定。

由科学家领导的研究MD AndersonCancer Centerhas shown that a simple molecule called 14-3-3 sigma could be one answer for explaining cancer metabolism, the chemical process by which a tumor forms, grows or dies.

“我们知道，所有的癌症成长学习如何改编他们的新陈代谢，”说Mong-Hong Lee, Ph.D., professor ofMolecular and Cellular Oncology。“但如何发生这种情况尚未完全understood. Our study showed that 14-3-3 sigma opposes and reverses tumor-promoting metabolic programs.”

Lee’s study results, which appeared inNature Communications, reveal new understanding about how 14-3-3 sigma — a cell cycle “controller” — regulates cancer metabolic programming, thus protecting healthy cells from turning into tumor-producing factories.

在体内和体外实验显示，在许多生化效应，14-3-3西格玛阻抑癌细胞glycosis，这防止癌症的能力将葡萄糖转化为丙酮酸，对细胞生长的物质是必不可少的。

“14-3-3 sigma expression levels can help predict overall and recurrence-free survival rates, tumor glucose uptake and metabolic gene expression in breast cancer patients,” Lee said. “These results highlight that 14-3-3 sigma is an important regulator of tumor metabolism, and loss of 14-3-3 sigma expression is critical for cancer metabolic reprogramming.”

李先生认为，研究结果提供有关癌症的代谢和细胞周期之间的“串扰”额外的洞察力。

“We anticipate that pharmacologically elevating 14-3-3 sigma’s function in tumors could be a promising direction for targeted anti-cancer metabolism therapy development in the future,” he said.