装配他的“他莫昔芬团队”

It’s the Friday before Father’s Day, and五，克雷格·乔丹博士, who’s considered the “Father of Tamoxifen,” is sitting down to talk about, among other things, the drug for which he’s best known, the class of drugs he plans to build in his lab at MD Anderson Cancer Center and his decision to come to Texas.

出生于新布朗福，得克萨斯州，在英国长大，乔丹拥有双重英国和美国国籍。2002年，他收到了来自英国女王伊丽莎白二世的大英帝国勋章为国际乳腺癌研究服务。188bet体育网址在他的空闲时间，他已经积累了古董武器藏品令人印象深刻，其中包括在英国各地的860公元做了海盗剑。

在他的成名作...

The National Academy of Sciences member played a key role in transforming a once-failed contraceptive medication into a valuable breast cancer treatment responsible for saving countless lives. The drug, later named tamoxifen, originally was created to block estrogen in the hopes of preventing pregnancy. Jordan discovered the drug could be used to block the estrogen that fuels estrogen receptor (ER)-positive breast cancer cells, and developed the strategy of using tamoxifen as a long-term adjuvant therapy. It’s used to treat all stages of breast cancer, ductal carcinoma in situ and male breast cancer.

他还描述并破译一个新的组的药物，其包括他莫昔芬，称为选择性雌激素受体调节剂（SERMs）的性质。他是第一个发现不仅他莫昔芬，而且雷洛昔芬预防的能力。美国食品和药物管理局（FDA）已经批准了两种药物用于降低高危妇女乳腺癌的发病率。

“今天，有五个SERM的是FDA批准。1980年，什么都没有。它彻底改变了的药“。

乳腺肿瘤内科和分子与细胞肿瘤的MD安德森焦点的教授是雌激素诱导的细胞死亡的新生物。他和他的“他莫昔芬队”将努力发展用于治疗和预防癌症的方法翻译。

Give us an update on the startup of your lab.

我目前正在搜集我的“他莫昔芬组。”它汇聚在今年夏天。有很多的变数 - 人们得到他们的学位，工作许可，签证。我们应该八月或九月有10人代替临界质量。

将您的工作最初的重点是什么，一旦实验室启动并运行？

内分泌或激素治疗失败如何?的再保险ason I came to MD Anderson is the opportunity to do translational research. We have all the best models from cell culture lines that you can get anywhere. But the reality now is we need it connected to patients. We want to create cell cultures that represent the spectrum of breast cancer. We want to make 50 breast cancer cell lines and link those to patient information. We then sequence all of this and the result is we have everyone’s cell lines.

我们想把他们放在一起模型系统的电池在实验室，让下一代研究来研究细胞系链接到患者的疾病。188bet体育网址但后来问的问题，“这种雌激素诱导的细胞凋亡，是什么让这些ER阳性乳腺癌在他们的基因揭露与应让他们活着的东西垂死的能力吗？”这是我们要通过研究骨重建，以解决问题。当雌激素在更年期妇女切断，发生骨质流失。巨噬细胞，从而破坏外来抗原，进入骨骼，这是开始腐烂，并开始清理。那些巨噬细胞基本上成为一个被称为破骨细胞的细胞，这破坏骨。但是，当雌激素回来到骨头会发生什么？它杀死的破骨细胞。

If we can look at the mechanism of how this happens, and we follow the estrogen receptor to where the target is in women’s breasts, that target becomes a “druggable” target for, maybe, any cancer. It could be a perfect symbiosis with what James Allison is doing with immunotherapy — using the body’s systems to protect itself. That’s where we want to go.

What appealed to you about MD Anderson?

对我来说，科学，具体，医学科学，是关于创建的变化，将有利于社会。这将有机会提供一些为社会和改造社会特权。而这种改变必须是在刀刃上。随着报价来MD安德森，I knew I would be in a great position to continue to bring about change.

Speaking of change, what changes do you see in the future that can be addressed today at MD Anderson?

随着人口的不断老化，还会有乳腺癌增加了50％。这将几乎完全雌激素受体阳性。我们现在做将使MD安德森是在为广大乳腺癌的雌激素受体阳性治疗中的佼佼者。所以这是一个战略决策，以应对下一代医生将面临增加以获得对疾病的手柄了。目前，乳腺癌80％的ER阳性，但这一比例有望提高到95％，随着人口老龄化。

和你熟悉的德州，是吧？

I was born in Texas, so coming back to Texas is like coming back to my natural home. As it turns out, my mother’s best friend, who she hasn’t seen for decades, lives two miles down the road from me. Whatever is in my native DNA — my father was from Dallas — seems to have brought me back here.

Now that you’ve been here a few months, what are your initial impressions of the institution?

We have a great opportunity here. The whole world is struggling with how we forge a future. We have limited resources, but I’m very impressed with what the state of Texas is doing through CPRIT. It’s a model that works. By funding cancer research, we can attract the brightest minds in the field to Houston. The resources atMD Andersonare second to none, and those resources are deployed optimally to give optimal health care, hire optimal faculty and conduct optimal research. There’s a vision of research here that says, “here’s what we need to do: end cancer. Now, let’s try and do it. Take what resources we have and answer real questions. Take everyone we have and bring them together to do it. Recruit people who can think outside the box.” The fact that the state has made a commitment to supporting that goal, and the fact that Chancellor (William) McRaven has a great vision for the future — all of this is why I want to be here. I can’t say there’s any place else that has this constellation of stars all lining up.