The resistance fighter
Historically, research and patient care have been kept separate or “siloed.” Guillermo Garcia-Manero wants to change that.
An expert in blood cancers and translational medicine, Garcia-Manero, M.D., professor in白血病,注意到,骨髓增生异常综合征(MDS),其中,所述骨髓不能产生足够的血细胞,通常建立到前线药物抗性如去甲基化药物。
反过来,这些患者发生急性髓系白血病(AML),当没有足够成熟的血细胞,防止贫血,感染或出血恰好。去甲基化剂,其靶DNA,消除快速分裂的细胞而不伤害正常的。
Through MD Anderson’sAML/MDS Moon Shot,加西亚 - Manero被揭示为耐药性的发展对这些药剂的分子基础。换句话说,他试图发现什么变化的时候,患者的身体抵抗药物发生,它停止工作。
Understanding these changes is critical, according to Garcia-Manero, because resistance to hypomethylating agents also correlates with resistance to other drugs and, ultimately, poor patient prognosis
Unlike the genome, the presence and activity of proteins vary in each cell to support its unique functions. Garcia-Manero anticipates that identifying changes in protein type, levels and modifications in cells — a process called proteomic analysis — will reveal biomarkers that predict sensitivity, response and/or resistance to drugs. It also may uncover targets for new therapies.
MD安德森白血病中心
- 在世界上最大的白血病程序
- 国际知名医师
- 更多than 150 active clinical trials
- Access to investigational agents
48,610 people diagnosed with leukemia in the U.S. in 2013
- 15,680 cases of chronic lymphocytic leukemia
- 14,590 cases of acute myeloid leukemia
- 6,070 cases of acute lymphocytic leukemia
- 5920例慢性骨髓leukemia