Study #2019-0184
Phase 1/2 Open-Label, Multi-center, Dose-escalation Study to Assess the Safety, Tolerability and Pharmacokinetics of Orally Administered Fimepinostat (CUDC-907)
MD Anderson Study Status
不接受
Treatment Agent
fimepinostat, Rituximab, venetoclax
Description
这是复发和/或难治性弥漫性大B细胞淋巴瘤(DLBCL)或高级B细胞淋巴瘤(HGBL)的患者中的1阶段1,开放标签,剂量升级研究有或没有Myc和Bcl2改变。FIMEPINOSTAT(CUDC-907)是一种用于抑制磷酸阳性3-激酶(PI3K)和组蛋白脱乙酰化酶(HDAC)的多目标试剂。该研究旨在评估安全性,最大耐受剂量,推荐的阶段2剂量(RP2D),药代动力学和口腔内肺蛋白酶的抗癌活性与1个或更多抗癌方案的组合。
信息和下一步
Disease:
Lymphoma, Relapsed Lymphoma, Refractory Lymphoma, Relapsed and/or Refractory Lymphoma, Relapsed Ddiffuse Large B-Cell Lymphoma (DLBCL), Refractory Diffuse Large B-Cell Lymphoma (DLBCL), Relapsed and/or Refractory Diffuse Large B-Cell Lymphoma (DLBCL), Double-hit Lymphoma (DHL), Triple-hit Lymphoma (THL), Double-expressor Lymphoma (DEL), High-grade B-cell Lymphoma (HGBL)
研究阶段:
I
医师名称:
Jason Westin
部门:
淋巴瘤/骨髓瘤
有关临床试验的一般问题:
1-877-632-6789
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