Protein ZMYND8 tied to suppression of prostate cancer tumor metastasis

Study reveals protein’s ability to block expression of metastasis-linked genes

MD Anderson News Release July 28, 2016

虽然读象欧洲车牌号，称为ZMYND8蛋白已表明它阻断前列腺癌转移联基因的能力，根据在研究The University of Texas MD Anderson Cancer Center。The findings, resulting from cell line and mouse model studies, are published in the July 28 online issue of分子细胞。

“这些结果是重要的，因为癌转移是一个复杂的过程，既破坏性和临床挑战，”说闵圭利，博士，副教授Molecular and Cellular Oncology。“对于转移，癌症细胞获得迁移和侵袭的能力，因此获得新的洞察如何发生以及如何阻止转移是至关重要的。我们相信，这项研究将打开一个窗口，进入这个过程。”

李的研究集中在基因调控，被称为组蛋白的蛋白质至关重要的修改。组蛋白修饰，包括乙酰化和甲基化的改变，经常与癌症发展有关。李组看着ZMYND8作为组蛋白“阅读器”，可以通过识别被称为组蛋白这些组蛋白修饰可能影响基因表达“的痕迹。”

“这已充分证明，组蛋白乙酰化和甲基化对基因表达的影响可以通过特定的结合蛋白称为介导的‘读者’，”李说。“我们确定ZMYND8为组蛋白标记称为H3K4me1和H3K14ac，这两者都依赖于转移连锁基因读者。”

The research group also noted that ZMYND8 cooperated with a type of histone mark “eraser” called JARID1D to suppress metastasis-linked genes.

“These findings are of special interest in light of our earlier study that JARID1D levels are lower in metastasized prostate tumors than in normal prostate and primary prostate tumors,” said Lee. “This study revealed a previously unknown metastasis-suppressive mechanism in which ZMYND8 counteracts the expression of metastasis-linked genes by reading dual histone marks H3K4me1 and H3K14ac and cooperating with JARID1D.”

研究小组的MD安德森成员包括李娜，博士，蔡，余晨，希尔帕达尔博士和浦叶侃，博士，所有的分子与细胞肿瘤的;和洪文博士和小冰石，博士，表观遗传学和分子致癌。

Other participating institutions included Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing; The Methodist Hospital Research Institute, Houston; Weill Cornell Medical College, New York City; Children’s Hospital, Fudan University, Shanghai; Bloomberg School of Public Health, The Johns Hopkins University, Baltimore; the University of Miami School of Medicine, Miami; Baylor College of Medicine, Houston; The University of Texas Graduate School of Biomedical Science, Houston; and West China Hospital, Sichuan University, Chengdu, China.

The study was funded by the National Institutes of Health (CA157919, GM095659, ES025761, HG007538, GM078455 and GM105754); the Cancer Prevention and Research Institute of Texas (RP110183, RP110471 and RP140323); the Ministry of Science and Technology of China (2016FA05000700); the Tsinghua University Initiative Scientific Research Program; The Robert A. Welch Foundation (G1719); the National Natural Science Foundation of China (31400633); and the China Postdoctoral Science Foundation (2014T70069).