Van Karlyle Morris, M.D.
胃肠道肿瘤内科，肿瘤医学部部
In the News
当前标题及所属机构
主要预约
Assistant Professor, Department of Gastrointestinal (GI) Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2016 | University of Texas Health Science Center, Houston, TX, USA, MS, Biomedical Sciences |
| 2008 | University of Tennessee Health Sciences Center, Memphis, TN, USA, MD, Doctor of Medicine |
| 2002 | 北卡罗莱纳州教堂山分校，北卡罗来纳州，美国，英国BS，化学的大学 |
Postgraduate Training
| 2014-2015 | Research Instructor, Department of Gastrointestinal Medical Oncology, University of Texas - MD Anderson Cancer Center, Houston, TX |
| 2011-2014 | Clinical Fellowship, Hematology / Oncology, Division of Cancer Medicine, University of Texas - MD Anderson Cancer Center, Houston, TX |
| 2009-2011 | Clinical Residency, Internal Medicine, Duke University, Durham, NC |
| 2008-2009 | Clinical Internship, Internal Medicine, Duke University, Durham, NC |
Experience & Service
Other Appointments/Responsibilities
Undergraduate Researcher, University of North Carolina, Chapel Hill, NC, 2001 - 2002
荣誉与奖励
| 2015 | Khalifa Scholar Award, MD Anderson Cancer Center |
| 2014 | Achievement in Clinical Investigation, MD Anderson Cancer Center |
| 2013 | ASCO征服癌症基金会荣誉奖，美国临床肿瘤学会 |
| 2013 | Young Investigator Award, American Society of Clinical Oncology |
| 2010 | Barton Haynes Housestaff Research Award, Duke Department of Medicine |
| 2008 | Alpha Omega Alpha, University of Tennessee College of Medicine |
| 2008 | Robert L. Summit, M.D. Distinguished Student Achievement Award, University of Tennessee College of Medicine |
| 2008 | University of Tennessee Health Science Center Distinguished Student Service Award, University of Tennessee College of Medicine |
| 2002 | American Institute of Chemists Graduation Award, University of North Carolina |
| 2002 | Graduate with Highest Honors, University of North Carolina Department of Chemistry |
| 2001 | 菲贝卡，北卡罗莱纳大学 |
Selected Publications
Peer-Reviewed Articles
- Pereira AA, Rego JF,Morris VK，超人MJ，主机C，盖瑞特CR，布廷AT，Ferrarotto R，李男，姜ZQ，霍夫PM，沃泰JN，维拉尔E，丸d，Kopetz小号。Association between KRAS mutation and lung metastasis in advanced colorectal cancer. Br J Cancer 112(3):424-8, 2015. e-Pub 2014. PMID: 25535726.
- Morris VK, Lucas FA, Overman MJ, Eng C, Morelli MP, Jiang ZQ, Luthra R, Meric-Bernstam F, Maru D, Scheet P, Kopetz S, Vilar E。Clinicopathologic characteristics and gene expression analyses of non-KRAS 12/13, RAS-mutated metastatic colorectal cancer. Ann Oncol 25(10):2008-14, 2014. e-Pub 2014. PMID: 25009008.
- Morris VK，超人MJ，姜ZQ，盖瑞特C，瓦尔S，主机C，记B，福格尔曼d，Dasari A，沃尔夫R，丸d，Kopetz小号。Progression-free survival remains poor over sequential lines of systemic therapy in patients with BRAF-mutated colorectal cancer. Clin Colorectal Cancer 13(3):164-71, 2014. e-Pub 2014. PMID: 25069797.
- Kopetz S,Morris VK, Parikh N, Overman MJ, Jiang ZQ, Maru D, Elvin P, Gallick G。Src activity is modulated by oxaliplatin and correlates with outcomes after hepatectomy for metastatic colorectal cancer. BMC Cancer 14:660, 2014. e-Pub 2014. PMID: 25208577.
- Morris VK, Kopetz S。Clinical biomarkers in colorectal cancer. Clin Adv Hematol Oncol 11(12):768-76, 2013. PMID: 24893280.
- Morris VK, Kopetz S。BRAF inhibitors in clinical oncology. F1000Prime Rep 5:11, 2013. e-Pub 2013. PMID: 23585929.
- 雅布尔E，Morris VK，Kantarjian H，阴CC，伯顿E，科尔特斯Ĵ。患者V299L BCR-ABL特点和成果激酶结构域突变后的治疗与酪氨酸激酶抑制剂。血液120（16）：3382-3，2012。PMID：23086624。
- Morris VK, Spraker HL, Howard SC, Ware RE, Reiss UM。Severe thrombocytopenia with iron deficiency anemia. Pediatr Hematol Oncol 27(5):413-9, 2010. PMID: 20670168.
- Morris VK, Izard T。底物诱导的不对称性和信道闭合揭示的结核分枝杆菌磷酸泛酰腺苷酰转移酶的酶蛋白的结构。蛋白质科学13（9）：2547-52，2004。PMID：15322293。
- Brown KL,Morris VK, Izard T。Rhombohedral crystals of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase. Acta Crystallogr D Biol Crystallogr 60(Pt 1):195-6, 2004. e-Pub 2003. PMID: 14684928.
Abstracts
- Hong DS,Morris VK，埃尔乌斯塔B，索罗金AV，Janku号富S，超人MJ，皮哈保S，Subbiah V，记B，Tsimberidou A，福格尔曼d，BellidoĴ，Shureiqi I，黄H，阿特金斯Ĵ，Tarcic G，Sommer的N，兰曼R，梅里克-Bernstam楼Kopetz小号。Phase 1B Study of Vemurafenib in Combination with Irinotecan and Cetuximab in Patients with Metastatic Colorectal Cancer with BRAF V600E Mutation. ASCO Annual Meeting, 2016. PMID: 27729313.
- Morelli MP, Overman MJ, Dasari A, Kazmi SM, Mazard T, Vilar E,Morris VK, Lee MS, Herron D, Eng C, Morris J, Kee BK, Janku F, Deaton FL, Garrett C, Maru D, Diehl F, Angenendt P, Kopetz S。Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment. Ann Oncol 26(4):731-6, 2015. e-Pub 2015. PMID: 25628445.
Book Chapters
- Morris VK。Colorectal Cancer. In: The MD Anderson Manual of Medical Oncology 3rd edition, 2016.
- Morris VK。Anal Cancer. In: The MD Anderson Manual of Medical Oncology 3rd edition, 2016.
Grant & Contract Support
| Title: | Epigenetics of BRAF-mutated colorectal cancer |
| Funding Source: | American Society of Clinical Oncology (ASCO) |
| Role: | Principal Investigator |
| Title: | Patient-derived xenografts: a co-clinical trial for BRAF-mutant colorectal cancer |
| Funding Source: | SWOG Hope Foundation Award |
| Role: | Co-Principal Investigator |
| Title: | Wnt modulation as a therapeutic target in metastatic colorectal cancer |
| Funding Source: | Khalifa Scholar Award |
| Role: | Principal Investigator |
| Title: | 一期/转移性结直肠癌M7824的II期临床试验 |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |