Jeannelyn S Estrella,医学博士
Department of Pathology, Division of Pathology-Lab Medicine Div
现在的标题和隶属关系
主要任命
Associate Professor, Department of Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
教育与培训
学位授予教育
2005 | University of California, San Diego School of Medicine, La Jolla, CA, USA, MD, Doctor of Medicine |
1999 | 加利福尼亚大学圣地亚哥分校,美国加利福尼亚州,美国,BS,通用生物学 |
Postgraduate Training
2010-2011 | 德克萨斯州休斯敦的德克萨斯大学医学博士Anderson癌症中心临床奖学金,胃肠道和肝脏病理学 |
2009-2010 | 德克萨斯大学医学博士安德森癌症中心,德克萨斯州休斯敦的临床奖学金,手术病理学 |
2006-2009 | Clinical Residency, Anatomic Pathology, New York Presbyterian – Weill Cornell Medical College, New York, NY |
2005-2006 | 188bet体育网址加利福尼亚大学圣地亚哥大学医学院的研究奖学金,博士后,神经科学与病理学 |
荣誉与奖励
2016 | The Shirley Stein Scientific Endowment Research Award, UT MD Anderson Cancer Center |
2012 | Best Abstract Award, First Place, Texas Society of Pathology |
2011 | 杰西·H·琼斯(Jesse H. Jones)癌症教育奖,UT MD安德森癌症中心 |
2011 | Best Abstract Award, Second Place, Chinese American Pathologist Association (CAPA) |
1999 | 加利福尼亚大学圣地亚哥分校 |
选定的出版物
同行评审的文章
- Samdani RT, Wasylishen AR, Halperin DM, Dasari A, Yao JC, Rashid A,Estrella JS。胰腺神经内分泌肿瘤中免疫组织化学通过免疫组织化学的表达丧失:原发性和转移性肿瘤之间的比较。胰腺48(4):510-513,2019。E-PUB2019。PMID:30946241。
- Wasylishen AR,Estrella JS,Pant V,Chau GP,Lozano G。Daxx Functions are p53-independent In Vivo. Mol Cancer Res 16(10):1523-1529, 2018. e-Pub 2018. PMID: 29903771.
- ikoma n,Estrella JS, Blum M, Das P, Chen HC, Wang X, Fournier K, Mansfield P, Ajani J, Badgwell BD。胃癌中的中枢淋巴结转移可以预测术前治疗后的生存。J Gastrointest Surg 22(8):1325-1333,2018。E-PUB2018。PMID:29679346。
- ikoma n,Estrella JS,Hofstetter W,Das P,Minsky BD,Ajani JA,Fournier KF,Mansfield P,Badgwell BD。Nodal Downstaging in Gastric Cancer Patients: Promising Survival if ypN0 is Achieved. Ann Surg Oncol 25(7):2012-2017, 2018. e-Pub 2018. PMID: 29748883.
- Ikoma N,Hofstetter WL,Estrella JS, Das P, Minsky BD, Fournier KF, Mansfield PF, Ajani JA, Badgwell BD。The ypT category does not impact overall survival in node negative gastric cancer. J Surg Oncol 117(8):1721-1728, 2018. e-Pub 2018. PMID: 29949666.
- Ikoma N,Blum M,Estrella JS,Das P,Hofstetter WL,Fournier KF,Mansfield P,Ajani JA,Badgwell BD。Evaluation of the American Joint Committee on Cancer 8th edition staging system for gastric cancer patients after preoperative therapy. Gastric Cancer 21(1):74-83, 2018. e-Pub 2017. PMID: 28643144.
- Ajani JA, Estrella JS, Chen Q, Correa AM, Ma L, Scott AW, Jin J, Liu B, Xie M, Sudo K, Shiozaki H, Badgwell B, Weston B, Lee JH, Bhutani MS, Onodera H, Suzuki K, Suzuki A, Ding S, Hofstetter WL, Johnson RL, Bresalier RS, Song S。Galectin-3表达在弥漫型胃腺癌中是预后的,赋予了侵略性表型,并且可以由YAP1/BET抑制剂靶向。Br J Cancer 118(1):52-61,2018。E-PUB2017。PMID:29136404。
- Elimova E,Slack RS,Chen HC,Planjery V,Shiozaki H,Shimodaira Y,Charalampakis N,Lin Q,Harada K,Wadhwa R,Wadhwa R,Estrella JS,Kaya DM,Sagebiel T,Lee JH,Weston B,Bhutani M,Murphy MB,Matamoros A,Minsky B,Das P,Mansfield PF,Badgwell BD,Ajani JA。有或没有辅助治疗的手术的局部胃腺癌患者的复发模式:监测的成本和有效性。Oncotarget 8(46):81430-81440,2017。E-PUB2017。PMID:29113402。
- ikoma n,Chen HC, Wang X, Blum M,Estrella JS, Fournier K, Mansfield P, Ajani J, Badgwell BD。Patterns of Initial Recurrence in Gastric Adenocarcinoma in the Era of Preoperative Therapy. Ann Surg Oncol 24(9):2679-2687, 2017. e-Pub 2017. PMID: 28332034.
- Charalampakis N,Xiao L,Lin Q,Elemova E,Shimodaira Y,Harada K,Rogers JE,Mares J,Amlashi FG,Minsky BD,Das P,Das P,Hofstetter WL,Matamoros A,Matamoros A,Sagebiel TL,Blum-Murphy MA,Lee JH,Lee JH,Lee JH,Lee JH,Lee JH,Weston B,Bhutani MS,Mansfield PF,Estrella JS,Badgwell BD,Ajani JA。接受胃食管治疗术前治疗的患者的合并症而不是年龄影响结果。Ann Surg Oncol 24(8):2291-2301,2017。E-PUB2016。PMID:27770339。
- Mizrak Kaya D, Dong X, Nogueras-González GM, Xu Y,Estrella JS,Harada K,Lopez A,Amlashi FG,Hofstetter WL,Maru DM,Nguyen QN,Lee JH,Weston B,Bhutani MS,Erasmus JJ,Thomas I,Rogers JE,Song S,Song S,Ajani JA,Ajani JA。Post-trimodality expression levels of metadherin (MTDH) as a prognostic biomarker for esophageal adenocarcinoma patients. Med Oncol 34(8):135, 2017. e-Pub 2017. PMID: 28685276.
- Agnes A,Estrella JS,羽毛球b。The significance of a nineteenth century definition in the era of genomics: linitis plastica. World J Surg Oncol 15(1):123, 2017. e-Pub 2017. PMID: 28679451.
- ikoma n,Blum M, Chiang YJ,Estrella JS,Roy-Chowdhuri S,Fournier K,Mansfield P,Ajani J,Badgwell BD。种族是胃癌患者淋巴结转移的风险。Ann Surg Oncol 24(4):960-965,2017。E-PUB2016。PMID:27778127。
- Roland CL,Starker LF,Kang Y,Chatterjee D,Estrella J,Rashid A,Katz MH,Aloia TA,Lee JE,Dasari A,Yao JC,Fleming JB。Loss of DPC4/SMAD4 expression in primary gastrointestinal neuroendocrine tumors is associated with cancer-related death after resection. Surgery 161(3):753-759, 2017. e-Pub 2016. PMID: 27816207.
- Saab J,Estrella JS,Chen YT和Yantiss RK。胃增生息肉的免疫组织化学和分子特征。Adv Cytol Pathol 2(1):00012,2017。
- ikoma n,Blum M, Chiang YJ,Estrella JS,Roy-Chowdhuri S,Fournier K,Mansfield P,Ajani JA,Badgwell BD。Yield of Staging Laparoscopy and Lavage Cytology for Radiologically Occult Peritoneal Carcinomatosis of Gastric Cancer. Ann Surg Oncol 23(13):4332-4337, 2016. e-Pub 2016. PMID: 27384751.
- Conte B,George B,Overman M,Estrella JS,Jiang ZQ,Mehrvarz Sarshekeh A,Ferrarotto R,Hoff PM,Rashid A,Yao JC,Kopetz S,Dasari A。高级神经内分泌结肠癌:100例患者的回顾性研究。临床结直肠癌15(2):E1-7,2016。E-PUB2015。PMID:26810202。
- Badgwell B,Blum M,Elemova E,Estrella J,Chiang YJ,Das P,Mansfield P,Ajani J。Frequency of Resection After Preoperative Chemotherapy or Chemoradiotherapy for Gastric Adenocarcinoma. Ann Surg Oncol 23(6):1948-55, 2016. e-Pub 2016. PMID: 26868957.
- Charalampakis N, Nogueras González GM, Elimova E, Wadhwa R, Shiozaki H, Shimodaira Y, Blum MA, Rogers JE, Harada K, Matamoros A, Sagebiel T, Das P, Minsky BD, Lee JH, Weston B, Bhutani MS,Estrella JS,Badgwell BD,Ajani JA。The Proportion of Signet Ring Cell Component in Patients with Localized Gastric Adenocarcinoma Correlates with the Degree of Response to Pre-Operative Chemoradiation. Oncology 90(5):239-47, 2016. e-Pub 2016. PMID: 27046280.
- Fischer LK, Katz MH, Lee SM, Liu L, Wang H, Varadhachary GR, Wolff RA, Lee JE, Maitra A, Roland CL, Fleming JB,Estrella JS, Rashid A, Wang H。阳性淋巴结的数量和比率会影响新辅助治疗和胰十二指肠切除术后胰腺癌患者的生存。组织病理学68(2):210-20,2016。E-PUB2015。PMID:25945396。
- Shiozaki H, Elimova E, Slack RS, Chen HC, Staerkel GA, Sneige N, Shimodaira Y, Sagebiel T, Lee JH, Bhutani MS, Das P, Mansfield PF,Estrella JS,Badgwell BD,Ajani JA。胃腺癌患者的预后有各种负担腹膜转移。J Surg Oncol 113(1):29-35,2016。E-PUB2015。PMID:26603684。
- Estrella JS,Tetzlaff MT,Bassett RL,Patel KP,Williams MD,Curry JL,Rashid A,Hamilton SR,Broaddus RR。BRAF V600E结直肠癌状态的评估:免疫组织化学和测序之间的组织特异性不一致。Mol Cancer Ther 14(12):2887-95,2015。E-PUB2015。PMID:26438153。
- Charalampakis N,Xiao L,Elimova E,Wadhwa R,Shiozaki H,Shimodaira Y,Blum MA,Planjery V,Rogers JE,Matamoros A,Sagebiel T,Das P,Das P,Lee JH,Bhutani,Bhutani MS,Weston B,Weston B,,Weston B,,Weston B,,B.Estrella JS,Badgwell BD,Ajani JA。正电子发射断层扫描的初始标准化摄取值会影响术前治疗的局部胃腺癌患者的预后。肿瘤学89(6):305-10,2015年。E-PUB2015。PMID:26393501。
- Liu L, Katz MH, Lee SM, Fischer LK, Prakash L, Parker N, Wang H, Varadhachary GR, Wolff RA, Lee JE, Pisters PW, Maitra A, Fleming JB,Estrella JS, Rashid A, Wang H。胰腺导管腺癌患者的胰十二指肠切除术和预后的上肠系膜上动脉缘上的肠系膜动脉缘。Am J Surg Pathol 39(10):1395-403,2015。E-PUB2015。PMID:26200098。
- Estrella JS,Wang H,Bhosale PR,Evans HL,Abraham SC。Malignant Solitary Fibrous Tumor of the Pancreas. Pancreas 44(6):988-94, 2015. PMID: 26166470.
- Tetzlaff MT, Pattanaprichakul P, Wargo J, Fox PS, Patel KP,Estrella JS,Broaddus RR,Williams MD,Davies MA,Routbort MJ,Lazar AJ,Woodman SE,Hwu WJ,Gershenwald JE,Prieto VG,Torres-Cabala CA,Curry JL。BRAF V600E免疫组织化学表达模式作为154例晚期黑色素瘤患者的BRAF突变状态的替代性。Hum Pathol 46(8):1101-10,2015。E-PUB2015。PMID:26058727。
- Badgwell B,Blum M,Estrella JS,Chiang YJ,Das P,Matamoros A,Fournier K,Mansfield P,Ajani J。Predictors of Survival in Patients with Resectable Gastric Cancer Treated with Preoperative Chemoradiation Therapy and Gastrectomy. J Am Coll Surg 221(1):83-90, 2015. e-Pub 2015. PMID: 26002780.
- emimova e,wadhwa r,Shiozaki H, Sudo K,Estrella JS,羽毛球bD, Das P, Matamoros A, Song S, Ajani JA。Molecular biomarkers in gastric cancer. J Natl Compr Canc Netw 13(4):e19-29, 2015. PMID: 26052595.
- Elimova E, Shiozaki H, Slack RS, Chen HC, Wadhwa R, Sudo K, Charalampakis N, Hiremath A,Estrella JS,Matamoros A,Sagebiel T,Das P,Rogers JE,Garris JL,Blum MA,Badgwell B,Ajani JA。Early versus Delayed Therapy of Advanced Gastric Cancer Patients - Does It Make a Difference?. Oncology 89(4):215-20, 2015. e-Pub 2015. PMID: 26159599.
- Estrella JS, Ma LT, Milton DR, Yao JC, Wang H, Rashid A, Broaddus RR。胰腺神经内分泌肿瘤中雌激素诱导的基因和雌激素受体β的表达:对靶向治疗的影响。胰腺43(7):996-1002,2014。
- Estrella JS, Taggart MW, Rashid A, Abraham SC。在肠道腺瘤中产生的低度神经内分泌肿瘤:腺瘤性息肉病大肠杆菌/β-catenin途径改变的证据。Hum Pathol 45(10):2051-8,2014。E-PUB2014。PMID:25149552。
- Elimova E, Shiozaki H, Wadhwa R, Sudo K, Chen Q,Estrella JS,Blum MA,Badgwell B,Das P,Song S,Ajani JA。胃癌的医疗管理:2014年更新。World J Gastroenterol 20(38):13637-13647,2014。PMID:25320502。
- Li Y,Liu Z,Liu H,Wang LE,Onodera H,Suzuki A,Suzuki K,Wadhwa R,Elemova E,Sudo K,Shiozaki H,Shiozaki H,Estrella JS,Lee JS,Song S,Tan D,Ajani JA,Wei Q。核心核苷酸切除修复基因的潜在功能变异预测日本胃癌患者的存活率。致癌作用35(9):2031-8,2014。E-PUB2014。PMID:24990617。
- Estrella JS,Broaddus RR,Mathews A,Milton DR,Yao JC,Wang H,Rashid A。Progesterone Receptor and PTEN Expression Predict Survival in Patients with Low and Intermediate Grade Pancreatic Neuroendocrine Tumors. Arch Pathol Lab Med 138(8):1027-1036, 2014. PMID: 25076292.
- Estrella JS,Li L,Rashid A,Wang H,Katz MH,Fleming JB,Abbruzzese JL,Wang H。胰腺的固体假乳腺癌肿瘤:来自单个机构的64例临床病理和生存分析。Am J Surg Pathol 38(2):147-57,2014。PMID:24418850。
- emimova e,wadhwa r,Estrella JS, Sudo K, Shiozaki H, Blum MA, Chen Q, Song S, Das P, Ajani JA。Anal canal cancer: Biology and therapy. Expert Opinion on Orphan Drugs 2(2):137-146, 2014.
- Chatterjee D, Katz MH, Rashid A,Estrella JS,Wang H,Varadhachary GR,Wolff RA,Lee JE,Pisters PW,Abbruzzese JL,Fleming JB,Wang H。Pancreatic intraepithelial neoplasia and histological changes in non-neoplastic pancreas associated with neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma. Histopathology 63(6):841-51, 2013. e-Pub 2013. PMID: 24111684.
- Estrella JS,Othman ML,Taggart MW,Hamilton SR,Curley SA,Rashid A,Abraham SC。Intrabiliary Growth of Liver Metastases: Clinicopathologic Features, Prevalence, and Outcome. Am J Surg Pathol 37(10):1571-9, 2013. e-Pub 2013. PMID: 23797727.
- Estrella JS, Wolf JK, Deavers MT。卵巢浆液性癌与独特的“有线和透明化”模式相关。Arch Pathol Lab Med 137(2):275-279,2013。PMID:23368871。
- 王J,Estrella JS, Peng L, Rashid A, Varadhachary GR, Wang H, Lee JE, Pisters PW, Vauthey JN, Katz MH, Gomez HF, Evans DB, Abbruzzese JL, Fleming JB, Wang H。肠系膜上静脉/门静脉静脉的组织学肿瘤受累可预测用新辅助化疗治疗的II期胰腺腺癌患者的预后不良。癌症118(15):3801-11,2012。E-PUB2011。PMID:22180096。
- Estrella JS, Rashid A, Fleming JB, Katz MH, Lee JE, Wolf RA, Varadhachary GR, Pisters PW, Abdalla EK, Vauthey JN, Wang H, Gomez HF, Evans DB, Abbruzzese JL, Wang H。用新辅助化学疗法治疗的胰腺导管腺癌患者的病后病理阶段和存活率。癌症118(1):268-77,2012。E-PUB2011。PMID:21735446。
- Suzuki A,Xiao L,Taketa T,Blum MA,Matamoros A,Chien PL,Mansfield PF,Fournier KF,Weston B,Lee JH,Bhutani MS,Estrella JS,Delclos Me,Krishnan S,Das P,Ajani JA。未经手术的化学处理治疗的局部胃癌:UT M. D. Anderson癌症中心经验。肿瘤学82(6):347-351,2012。E-PUB2012。PMID:22677933。
- Estrella JS,Hofstetter WL,Correa AM,Swisher SG,Ajani JA,Lee JH,Bhutani MS,Abraham SC,Rashid A,Maru DM。重复的肌肉粘膜侵袭具有淋巴结转移和无复发生存的风险,如粘膜内食管腺癌。Am J Surg Pathol 35(7):1045-53,2011。PMID:21602659。
- Estrella JS,Wu TT,Rashid A,Abraham SC。转移性癌对胃肠道的粘膜定植:原发性肿瘤的潜在模仿。Am J Surg Pathol 35(4):563-72,2011。PMID:21412071。
- Ubhi K,Peng K,Lessig S,Estrella JS,Adame A,Galasko D,Salmon DP,Hansen LA,Kawas CH,Masliah E。高龄痴呆症的神经病理学与Lewy身体:与阿尔茨海默氏病的比较。Neurosci Lett 485(3):222-7,2010年。E-PUB2010。PMID:20849919。
- Estrella JS, Nelson RN, Sturges BK, Vernau KM, Williams DC, LeCouteur RA, Shelton GD, Mizisin AP。猫糖尿病神经病中的内核微血管病理。Microvasc Res 75(3):403-10,2008。E-Pub2007。PMID:18207200。
- He B, Xu W, Santini PA, Polydorides AD, Chiu A,Estrella JS,Shan M,Chadburn A,Villanacci V,Plebani A,Knowles DM,Rescigno M,Cerutti A。Intestinal Bacteria Trigger T cell-independent Immunoglobulin A(2) Class Switching by Inducing Epithelial-cell Secretion of the Cytokine APRIL. Immunity 26(6):812-26, 2007. PMID: 17570691.
- Nguyen LQ,Estrella JS, Jett EA, Grunvald EL, Nicholson L, Levin DL。Acute Schistosomiasis in Nonimmune Travelers: Chest CT Findings in 10 Patients. AJR Am J Roentgenol 186(5):1300-3, 2006. PMID: 16632722.
- Sonoda K,Samdani RT,Ikoma N,Kaya DM,Blum-Murphy M,Ajani JA,Badgwell BD,Katz MH,Rashid A,Rashid A,Estrella JS。胰十二指肠切除术后残留胃中的胃癌:病例系列。J Surg Oncol。E-PUB2019。PMID:31498442。
- Mizrak Kaya D,Wang X,Harada K,Blum Murphy MA,Das P,Minsky BD,Estrella JS,Lin Q,Amlashi FG,Lee JH,Weston B,Bhutani MS,Matamoros A,Sagebiel T,Wu CC,Rogers JE,Thomas I,Thomas I,Maru DM,Skinner HD,Badgwell BD,Hofstetter WL,Ajani JA JA JA JA JA JA JA JA JA JA。101个患有转移性胃食管癌并接受局部合并治疗的长期幸存者。肿瘤学。E-Pub2017。PMID:28683449。
Book Chapters
- Estrella JS。免疫组织化学。在:分子诊断和个性化癌症医学原理。第一的。Lippincott Williams&Wilkins:宾夕法尼亚州费城,2013年96-102。
赠款和合同支持
Title: | FOXP3+肿瘤浸润淋巴细胞在EBV阳性淋巴皮瘤样胃癌中的作用 |
Funding Source: | Division of Pathology and Laboratory Medicine |
Role: | Mentor |
Title: | MicroRNA标志性预测IV期胰腺神经内分泌肿瘤中无进展生存的预测 |
Funding Source: | Institutional Research Grant - Clinical |
Role: | Principal Investigator |
Title: | Gastric cancer immunity and immunotherapy |
Funding Source: | UT MD Anderson Cancer Center SINF |
Role: | Collaborator |
Title: | MicroRNA标志性预测IV期胰腺神经内分泌肿瘤中无进展生存的预测 |
Funding Source: | 病理学系教师赠款 |
Role: | Principal Investigator |
Title: | 胰腺神经内分泌肿瘤中的microRNA表达谱 |
Funding Source: | Division of Pathology and Laboratory Medicine |
Role: | Mentor |
Title: | 胰腺神经内分泌肿瘤的机械基础 |
Funding Source: | 神经内分泌肿瘤研究基金会188bet体育网址 |
Role: | Collaborator |
Title: | (PQ4)组蛋白伴侣DAXX驱动胰腺神经内分泌肿瘤而不是导管腺癌的突变 |
Funding Source: | NIH/NCI |
Role: | Collaborator |
Title: | 晚期胰腺神经内分泌肿瘤的多维免疫分析 |
Funding Source: | The Neuroendocrine Tumor Research Foundation |
Role: | 联合调查员 |
Title: | 一项回顾性/预期可行性研究,用于评估使用JAX临床癌症小组未知癌症患者可起作用的突变 |
Funding Source: | Jackson Laboratory |
Role: | Collaborator |
Title: | 发现胃腺癌的腹膜转移的新型治疗策略 |
Funding Source: | 国防部(国防部) |
Role: | Collaborator |
Title: | Immune-Suppression and Tumor-Stromal Interaction Mediated by Galectin-3 in Gastric Cancer-Implications of Novel Therapeutic Strategies |
Funding Source: | 国防部(国防部) |
Role: | Collaborator |
Title: | 利用神经内分泌肿瘤中的免疫系统 |
Funding Source: | Conquer Cancer Foundation 2018 Career Development Award (CDA) |
Role: | 联合调查员 |